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Solved: SharePoint 2019 ERR_HTTP2_PROTOCOL_ERROR 

  1. Navigate to the registry key 2.HKEY_LOCAL_MACHINE\System\CurrentControlSet\Services\HTTP\Parameters.
  2. Add 2 new REG_DWORD values, EnableHttp2Tls and EnableHttp2Cleartext, to this registry key.
  3. Set both values to 0.
  4. Reboot the server 

refer to

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